碘化二甲基木防己的降压作用

HYPOTENSIVE EFFECT OF DIMETHYL TRILOBINE IODIDE (DTI)

摘要: 本文报告碘化二甲基木防己碱(DTI)降压作用的研究。DTI给麻醉动物静脉注射,对狗0.05～0.1 mg/kg使血压下降42.3～61.5%,持续1小时左右恢复至原血压水平;对猫0.00625～0.0125 mg/kg使血压下降26.5～43.5%,持续2～4小时恢复至原血压水平;对兔0.005～0.01 mg/kg使血压下降24.3～61.0%,5小时不能恢复至原血压水平;0.5～1.0 mg/kg使大鼠血压下降27.2～41.1%。DTI的降压作用机制主要与其对神经节的阻断作用有关。本药对小鼠口服和静注的LD₅₀分别为522.0 mg/kg及2.23 mg/kg。

Abstract: The hypotensive effect of dimethyl trilobine iodide (DTI) was studied in various anesthesized animals. In dogs, intravenous injection of DTI at the dosage of 0.05～0.1 mg/kg reduced the blood pressure by 42.3～61.5% which lasted about an hour. In cats, the blood pressure was reduced 26.5～43.5% by DTI 0.00625～0.0125mg/kg, the effect persisted 2～4 hours. When DTI 0. 005～0.01 mg/kg was administered to rabbits, the blood pressure was reduced 24.3～61.0%, which lasted more than 5 hours. When given to rats, DTI also decreased the blood pressure markedly. The mechanism of the hypotensive effect of DTI was believed to be related to its ganglionic blockade action.The acute oral and iv LD₅₀ in mice were found to be 522.0 mg/kg and 2.23 mg/kg, respectively.