卢志英, 赵淑媛, 袁小妹, 杨玉龙. 4-甲氧羰基芬太尼的4-N-丙酰基结构类似物的合成与镇痛活性J. 药学学报, 1990, 25(5): 336-339.
引用本文: 卢志英, 赵淑媛, 袁小妹, 杨玉龙. 4-甲氧羰基芬太尼的4-N-丙酰基结构类似物的合成与镇痛活性J. 药学学报, 1990, 25(5): 336-339.
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ZY Lu, SY Zhao, XM Yuan , YL Yang, . SYNTHESIS AND ANALGESIC ACTIVITY OF 4-N-PROPIONYL ANALOGS OF 4-METHOXYCARBONYL FENTANYLJ. Acta Pharmaceutica Sinica, 1990, 25(5): 336-339.
Citation: ZY Lu, SY Zhao, XM Yuan , YL Yang, . SYNTHESIS AND ANALGESIC ACTIVITY OF 4-N-PROPIONYL ANALOGS OF 4-METHOXYCARBONYL FENTANYLJ. Acta Pharmaceutica Sinica, 1990, 25(5): 336-339.
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4-甲氧羰基芬太尼的4-N-丙酰基结构类似物的合成与镇痛活性

SYNTHESIS AND ANALGESIC ACTIVITY OF 4-N-PROPIONYL ANALOGS OF 4-METHOXYCARBONYL FENTANYL

    摘要
  • 摘要: 本文报道了4-甲氧羰基芬太尼4-N-丙酰基结构改变衍生物的合成及其镇痛活性。试验结果表明,该类衍生物均具有典型吗啡样作用的性质。多数化合物具有很强的镇痛活性。其中1379,1385和1387的镇痛活性强于先导物4-甲氧羰基芬太尼。

     

    Abstract: In the present paper, the synthesis and analgesic activities of some 4-N-propionyl analogs of 4-methoxycarbonyl fentanyl are reported. In mouse hot plate test, most of these compounds showed strong narcotic analgesic activity. The analgesic activitesof compounds 1379, 1385 and 1387 were found to be more potent than that of 4-methoxycarbonyl fentanyl.

     

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