云南红豆杉中四个新紫杉烷类二萜化合物的分离和结构鉴定

lSOLATlON AND STRUCTURAL ELUClDATION OF FOUR NEW TAXANE DITERPENOlDS FROM TAXUS YUNNANENSIS

摘要: 自云南红豆杉(Taxus yunnanensis ChengetL.K.Fu)树皮的二氯甲烷提取部分又分离得到7个紫杉烷类二萜和生物碱,经光谱(IR,MS,¹HNMR,¹H-¹H’COSY,¹³C-¹HCOSY)解析推定4个新的紫杉烷类二萜涨化合物的结构为5-decinnamoyl-11-acetyl-19-hydroxyl taxagifine(I),2-deacetoxy-5.decinnamoyl taxinineJ(II),1-hydroxy-2,7,9-trideacetyl baccatinI(IV)和7-xyIosyl-10-deacetyl baccatinIII(VII),3个已知的紫杉烷类二苑和生物碱是5-decinnamoyI taxinineJ(III),7-xylosyl taxol(V)和7-xylosyl cephalomannine(VI),它们是首次从该植物中得到。

Abstract: Seven taxane diterpen oids and alk aloids have been isolated from the ethanolicextract of the bark of Taxus yunnanensis Cheng et L.K.Fu. Three were identified as the known taxanes:5-decinnamovyl taxinineJ ( III),7-xylosyl taxol(V)and 7-xylosyl cephalomannine(VI ).Thestructures of four new compounds were elucidated as 5- decinnamoyl-11-acetyl-19- hydroxy taxagifine(I),2- deacety-5- decinnamoyltaxinine J(II ,1-hydroxy-2,7,9-trideacetylbaccatin I(IV )and7- xylosyl-10- deacetoxybaccatin III(VII)by spectroscopic methods(MS,¹H NMR,¹H-¹H COSY,¹³CNMR, ¹³C-¹HCOSY).