大理藜芦碱B的结构及其绝对构型的确定

THE STRUCTURE AND ABSOLUTE CONFIGURATION OF VERTALINE B ISOLATED FROM VERATRUM TALIENSE LOSE. F.

摘要: 从云南产的大理藜芦(Veratrum taliense)的全草中分离得一个维藜芦碱类的新生物碱,命名为大理藜芦碱B(vertaline B,I)除了应用光谱分析测定其结构外,并对I的氢溴酸盐单晶进行了X-ray衍射分析,确定了I的绝对构型为(20R,22R,25S)22,26-缩亚胺胆甾烷-5-烯-3β,16β,20β-三醇(20R,22R,25S)22,26-epiminocholest-5-ene-3β,16β,20β-triol。此外,尚分离得二个已知甾体生物碱,介藜芦胺(jervine,Ⅱ)和狭叶藜芦碱乙(stenophlline B,Ⅲ)。

Abstract: Three steroidal alkaloids were isolated from the total plant of Veratrum taliense Lose. f. collected in Yunnan province, China. By means of MS, ¹HNMR, ¹³CNMR and physical constants, the study proved Ⅱ to be jervine, Ⅲ to be stenophylline B and established the structure of a new alkaloid——vertaline B(Ⅰ). The absolute configuration of Ⅰ was determined by X-ray as (20R, 22R, 25S) 22,26-epiminocholest-5-ene-3β-16β, 20β, -triol.