胡蔓藤碱乙和胡蔓藤碱丁的结构测定

ELUCIDATION OF THE STRUCTURES OF HUMANTENINE AND HUMANTENIRINE

摘要: 自马钱科(Loganiaceae)植物胡蔓藤(Gelsemium elegans Benth.)根的总生物碱中分离得到两个新的氧化吲哚生物碱,命名为胡蔓藤碱乙(humantenine)和胡蔓藤碱T(humanlenirine)。根据光谱(UV,IR,¹HNMR,¹³CNMR and MS)分析和衍生物制备,确定胡蔓藤碱乙和胡蔓藤碱丁的化学结构分别为式(Ⅰ)和(Ⅱ)。同时用X光单晶衍射解析进一步证明了胡蔓藤碱乙的化学结构。

Abstract: Two new oxindole alkaloids, humantenine and humantenirine, have been isolated from the root of Hu-Man-Teng (Gelsemium elegcms Benth.) (Loganiaceae). Based on spectra data (UV, IR, ¹H NMR, ¹³C NMR and MS) and preparation of derivatives, the structures of humantenine and humantenirine were elucidated as (Ⅰ)and (Ⅱ), respectively. The former was Confirmed by single-crystal X-ray analysis of its hydrobromide.