Abstract: AimTo study the mechanisms of sodium ferulate (SF) on inhibition of collagen synthesis in hepatic stellate cells. MethodsCollagen synthesis was analyzed by measuring ³H-proline incorporation. ELISA method was used to study the effect of SF on transforming growth factor β₁ (TGFβ₁) level in cultured HSC-T6 cell. The effect of SF on the TGFβ₁ activity in the supernatant of culture was analyzed by mink lung epithelial cell (Mv1Lu) proliferation inhibition by MTT assay. ResultsSF inhibited collagen synthesis in hepatic stellate cells stimulated with TGFβ₁. SF was shown to decrease TGFβ₁ level in the supernatant of HSC-T6 increased by oxidative stress. TGFβ₁ activity was intervened by SF. ConclusionSF could decrease collagen synthesis, with mechanism may be associated with that SF intervened TGFβ₁ activity, and reduced the level of TGFβ₁ increased by oxidative stress.