Abstract: In an attempt to search for novel antiplatelet aggregation agents,14 newcompounds(II₁～II₁₄ ) were synthesized on the basis of the structure feature of β-adrenergic agonistTrimetoquinol and found whose R-(+)-isomer is more potent than other agents used clinically. Allthese compounds were not reported in literature previously.Their chemical structures were determinedby elemental analysis, MS, ¹HNMR and IR. Preliminary pharmacological results showed that most of the compounds were active on ADP-induced platelet aggregation in mice(in vitro), among which II₃,II₅,II₇,II₈ and II₁₀ have strongerinhibitory activity.