陆启荣, 黄炳勋. 防治血吸虫病药物的研究 Ⅲ.呋喃、苯氧乙酸及苯氧乙烷衍生物的合成J. 药学学报, 1964, 11(2): 129-131.
引用本文: 陆启荣, 黄炳勋. 防治血吸虫病药物的研究 Ⅲ.呋喃、苯氧乙酸及苯氧乙烷衍生物的合成J. 药学学报, 1964, 11(2): 129-131.
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LU CHI-JUNG HWANG BING-SHIUN, . STUDIES ON ANTIBILHARIAL DRUGS——Ⅲ.SYTHESES OF FURAN,PHENOXYACETIC ACID AND ETHOXYPHENYL DERIVATIVESJ. Acta Pharmaceutica Sinica, 1964, 11(2): 129-131.
Citation: LU CHI-JUNG HWANG BING-SHIUN, . STUDIES ON ANTIBILHARIAL DRUGS——Ⅲ.SYTHESES OF FURAN,PHENOXYACETIC ACID AND ETHOXYPHENYL DERIVATIVESJ. Acta Pharmaceutica Sinica, 1964, 11(2): 129-131.
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防治血吸虫病药物的研究 Ⅲ.呋喃、苯氧乙酸及苯氧乙烷衍生物的合成

STUDIES ON ANTIBILHARIAL DRUGS——Ⅲ.SYTHESES OF FURAN,PHENOXYACETIC ACID AND ETHOXYPHENYL DERIVATIVES

    摘要
  • 摘要: 合成了五个呋喃类衍生物,經过动物試驗,发現5-硝基呋喃-2-丙烯酸-β-二乙氨基乙酯盐酸盐对小白鼠有輕微的預防日本血吸虫病感染的作用,其他四个化合物无效。合成了三个苯氧乙酸及苯氧乙烷衍生物以作动物試驗。試驗結果认为对小白鼠无預防或治疗日本血吸虫病的作用。

     

    Abstract: Five furans two phenoxyacetic acids and one ethoxyphenyl derivative were prepared and tested for therapeutic effect on schistosomiasis japonica in mice, Only the Hydrochloride of β-diethylaminoethyl ester of 3-(5-nitro-2-furyl) acrylic acid has slight preventive effect; the other serven compounds were found no preventive effect so far.

     

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