Abstract:
In the present paper, we report the synthesis and analgesic activity of a series of azabicycloalkanes derivatives which are 3-azabicyclo3,3,1nonanes(Ⅱ, Ⅲ), 3-azabicyclo3,2,1.octanes (Ⅳ)and 8-azabicyclo3,2,1octanes (Ⅴ) Preliminary pharmacological results showed that most of the compounds in this series possess strong analgesic activity. The analgesic potency of 3-(
β-phenylethyl)-9
β-methoxy-9
α-(mpropionoxyphenyl)-3-azabicyclo3,3,1 nonane (Ⅱ
a) corresponds to more than 2000 times that of morphine.
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