苦葛根中的新三萜成分

NEW TRITERPENOIDS FROM PURARIA PEDUNCULARIS

摘要: 目的　研究苦葛Pueraria peduncularis (Grah. ex Benth.) Benth.根的化学成分。方法　用各种色谱技术进行分离，得到3个五环三萜化合物，用IR，MS，¹HNMR，¹³CNMR（DEPT），HMQC，HMBC，NOESY和NOE差谱鉴定化合物。结果　经光谱鉴定化合物1为3-O-［β-D-吡喃葡糖基(1→3)-O-β-D-吡喃葡糖醛酸基］-15α-羟基齐墩果-12烯-16-酮，化合物2为3β,15α-二羟基齐墩果-12烯-16-酮，化合物3为3β,16β-二羟基齐墩果-12烯-15-酮。结论　1和3为新化合物， 1被命名为苦葛皂苷A， 3被命名为苦葛二醇， 2为首次从苦葛根中分得。

Abstract: AIM　To study the chemical constituents of the roots of Pueraria peduncularis (Grah. ex Benth.) Benth.. METHODS　Compounds were isolated by using various kinds chromatography. Their structures were identified on the basis of spectral analysis. RESULTS　The structures of three pentacyclic triterpenoids were elucidated as 3-O-［β-D-glucopyranosyl(1→3)-O-β-D-glucuronopyranosyl］-15α-hydroxy-olean-12-en-16-one (1), 3β,15α-dihydroxy-olean-12-en-16-one (2) and 3β,16β-dihydroxy-olean-12-en-15-one (3). CONCLUSION　Compounds 1 and 3 were shown to be new compounds, 1 was named peduncularisaponin A, 3 was named peduncularisadiol, 2 was isolated for the first time from the root of this plant.