烟酰胺类和吡啶丙烯酰胺类衍生物的合成及扩血管活性

傅焕建; 朱莉亚; 林紫云

傅焕建, 朱莉亚, 林紫云. 烟酰胺类和吡啶丙烯酰胺类衍生物的合成及扩血管活性J. 药学学报, 1996, 31(9): 715-720.

引用本文:

傅焕建, 朱莉亚, 林紫云. 烟酰胺类和吡啶丙烯酰胺类衍生物的合成及扩血管活性J. 药学学报, 1996, 31(9): 715-720.

HJ Fu, LY Zhu , ZY Lin, . SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIESJ. Acta Pharmaceutica Sinica, 1996, 31(9): 715-720.

Citation:

HJ Fu, LY Zhu , ZY Lin, . SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIESJ. Acta Pharmaceutica Sinica, 1996, 31(9): 715-720.

烟酰胺类和吡啶丙烯酰胺类衍生物的合成及扩血管活性

SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIES

HJ Fu,
LY Zhu , ZY Lin,

摘要

Abstract: Eighteen nicotinamides(I_1～12)and pyridylacrylamides(II_1～15)have beensynthesized. All synthesized amides were submitted to phannacological screening and 0.1um·L^-1(10^-7M)-noradrenaline induced contraction of the rat aortic strip was taken aS criterion,The amidesI_3,4 and II_1,2 showed more potent vasodilating activity than compounds I_12,13 and II_3,4.

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