电导率-含水量曲线法与目测法确定O/W型微乳成型临界值的比较
Comparison of conductivity-water content curve and visual methods for ascertaintation of the critical water content of O/W microemulsions formation
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摘要:
以本实验室制备的15个O/W型空白微乳处方及按照文献所得的8个O/W型空白微乳处方共23个处方为样本, 比较电导率-含水量曲线法与目测法测定各处方空白微乳成型的临界值, 分析目测法确定O/W型微乳成型临界点的缺陷和不足, 探讨电导率-含水量曲线法的理论依据和科学意义。结果表明, 电导率-含水量曲线法在确定O/W型微乳成型临界点时与目测法具有显著性差异 (P < 0.001), 电导率-含水量曲线法测定值大于目测法测定值。结果证明, 目测法存在着缺陷和不足, 提示目测法测定的“临界含水量”值可能在双连续相微乳区域, 而电导率-含水量曲线法具备理论可行性及科学意义。
Abstract:This study is to screen 23 blank O/W type microemulsion (ME) samples, that is 15 samples from our laboratory, and 8 samples from literatrue; compare the conductivity-water content curve (CWCC) method and visual method in determining the critical water content during O/W type MEs’ formation, to analyze the deficiency and the feasibility of visual method and to exploxe scientific meanings of CWCC method in judging the critical water content of O/W type MEs during formation. The results show that there is a significant difference between the theoretical feasible CWCC method and visual method in determining the critical water content (P < 0.001), and the results judged by conductivity is higher than that by eye-based water content. Therefore, this article firmly confirmed the shortcomings of visual method and suggested that the eye-base “critical water content” may falls into continuous ME stage during O/W MEs’ formation. Further more, the CWCC method has theoretical feasibility and scientific meanings in determining the critical water content of O/W type MEs during formation.
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