糙叶败酱中木脂素成分研究糙叶败酱中木脂素成分研究

Studies on the lignans from Patrinia scabra

摘要: 目的研究糙叶败酱（Patrinia scabra Bge.）中的木脂素类化学成分。方法应用柱色谱HPLC法分离纯化，通过光谱（IR，MS，¹HNMR，¹³CNMR，DEPT，HMQC和HMBC）鉴定其化学结构。结果和结论分离并鉴定了4个木脂素类化合物，分别鉴定为：落叶松脂醇(1)，4-［1-乙氧基-1-(4′-羟基-3′-甲氧基)苯基］甲基-2-(4-羟基-3-甲氧基)苯基-3-羟甲基四氢呋喃(2)，异落叶松树脂酚(3)，去甲络石糖苷(4)。化合物2为新的木脂素，化合物3，4为首次从该属植物中分得。

Abstract: AimTo study the lignans from Patrinia scabra Bunge. MethodsThe constituents were separated and purified by column chromatography with silical gel, RP-silical gel and Sephadex LH-20. Their structures were identified on the basis of spectral data (IR, MS, ¹HNMR, ¹³CNMR, HMQC and HMBC). Results and ConclusionA new lignan was obtained and its structure was elucidated as 4-［1-ethoxyl-1-(4-hydroxy-3-methoxy)benzyl］methyl-2-(4-hydroxy-3-methoxy)benzyl-3-hydroxymethyl-tetrahydro-furan (2), along with three known lignans, lariciresinol (1)，isolariciresinol (3) and nortracheloside (4).