The change of drug development pattern pushes the innovation of drug valuation methods.  The pharmacokinetic research of traditional Chinese medicines (TCM) is an important part of TCM modernization and plays a key role in novel drug development of TCM.  However, the research methods and techniques are in consistent with the specific characteristics of TCM, i.e., multiple-components is still in the infant.  This review makes a brief summary of current pharmacokinetic exploration of TCM, metabonomics and complex network, and puts forward a new strategy based on complex network and metabonomics to study TCM pharmacokinetic in order to disclose the active components and mechanism of TCM.