Abstract: S-(5-nitro-2-furoyl)thiosemicarbazones and S- (5-nitro-2-furoyl) -substituted thiosemi- carbazones were prepared by reaction of 5-nitro-2-furoyl chloride with thiosemicarbazide or substituted thiosemicarbazides in dry acetone, or with thiosemica rbazones in dry tetra- hydrofuran in the presence of sodium bicarbonate. Similarly, alkylene-bis -S- (5-nitro-2- furoyl)-thiosemicarbazones and phenylene-bis--S-(5-nitro-2-furoyl)-thiosemicarbazones were prepared by using two equivalent weight of 5-nitro-2-furoyl chloride. The resulted compounds were screened in mice against schistosomiasis japonica. The results indicated that two compounds, S- (5-nitro-2-furoyl) -acetone-benzyl-thiosemicarbazone (Ⅳ) and S- (5-nitro-2-furoyl) -butanone-thiosemicarbazone (Ⅺ), possessed some chemoprophylactic activity.