三尖杉中的微量生物碱

STUDIES ON THE MINOR ALKALOIDS OF CEPHALOTAXUS FORTUNEI HOOK. F.

摘要: 自分离海南粗榧内酯和海南粗榧新碱后剩余的三尖杉Cephalotaxus fortunei Hook.f.的弱碱部分,又分出了5种微量生物碱(碱Ⅰ～Ⅴ)。碱Ⅱ和Ⅴ分别鉴定为3-表甲基西哈灭里辛碱B(3-epimethylscheIhammericine B和3-表西哈灭里辛碱3-epischelhammericine,均为首次报道存在于三尖杉中。碱Ⅲ鉴定为异三尖杉酮碱isocephalotaxinone,系首次自植物中分得。碱Ⅳ是一种新生物碱,根据物理常数和光谱分析,推定其结构如Ⅳ所示,命名为表福建三尖杉碱2-epicephal of ortuneine)。碱Ⅰ的结构待进一步研究。

Abstract: Five minor alkaloids were isolated from Cephalotaxus fortunei Hook. f. Alkaloids Ⅱ and Ⅴ were identified as 3-epimethylschelhammericine B and 3-epischelhammericine. Both were first reported to be present in this plant. Alkaloid Ⅲ was identified as isocephalotaxinone which was isolated from natural source for the first time. Alkaloid Ⅳ is a new alkaloid. Its structure was postulated to be Ⅳ by spectroscopic analysis and designated as 2-epicephalofortuneine.Structure determination of alkaloid I is still underway.