潘建林, 王彦广, 陈耀祖. 表鬼臼毒素羧酸酯的合成及体外抗肿瘤活性J. 药学学报, 1997, 32(12): 898-901.
引用本文: 潘建林, 王彦广, 陈耀祖. 表鬼臼毒素羧酸酯的合成及体外抗肿瘤活性J. 药学学报, 1997, 32(12): 898-901.
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JL Pan, YG Wang , YZ Chen, . SYNTHESIS OF EPIPODOPHYLLOTOXIN CARBOXYLATES AND ANTITUMOR ACTIVITY IN VITROJ. Acta Pharmaceutica Sinica, 1997, 32(12): 898-901.
Citation: JL Pan, YG Wang , YZ Chen, . SYNTHESIS OF EPIPODOPHYLLOTOXIN CARBOXYLATES AND ANTITUMOR ACTIVITY IN VITROJ. Acta Pharmaceutica Sinica, 1997, 32(12): 898-901.
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表鬼臼毒素羧酸酯的合成及体外抗肿瘤活性

SYNTHESIS OF EPIPODOPHYLLOTOXIN CARBOXYLATES AND ANTITUMOR ACTIVITY IN VITRO

    摘要
  • 摘要: 在三氟化硼·乙醚的催化作用下,鬼臼毒素(I)与有机酸直接脱水生成了具有4β-构型的表鬼臼毒素羧酸酯(IIa～g),所有合成产物经IR,1HNMR,MS和元素分析等确证其结构,初步药理试验表明,该类化合物对小鼠白血病P388、人胃癌SGC-7901有一定的抑制活性。

     

    Abstract: A series of epipodophyllotoxin carboxylates were prepared from podophyllotoxin by reacting with organic acids under the catalysis of BF3·Et2O. All these products were characterized through IR, 1HNMR, MS and elemental analysis.These compounds showed significant antitumor activities against mouse leukemia P388 and human stomach cancer SGC-7901 in pharmacological tests in vitro.

     

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