刘懋勤, 迟传金, 郭幼梅, 朱淬砺. 长效镇痛药14-羟基可待因酮和14-羟基吗啡酮腙类衍生物的合成J. 药学学报, 1983, 18(6): 475-477.
引用本文: 刘懋勤, 迟传金, 郭幼梅, 朱淬砺. 长效镇痛药14-羟基可待因酮和14-羟基吗啡酮腙类衍生物的合成J. 药学学报, 1983, 18(6): 475-477.
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LIU Mao-qin, CHI Chuan-Jin, GUO You-mei , ZHU Cui-li, . SYNTHESIS OF LONG-ACTING ANALGETIC HYDRAZONE DERIVATIVES OF 14-HYDROXYCODEINONE AND 14-HYDROXYMORPHINONEJ. Acta Pharmaceutica Sinica, 1983, 18(6): 475-477.
Citation: LIU Mao-qin, CHI Chuan-Jin, GUO You-mei , ZHU Cui-li, . SYNTHESIS OF LONG-ACTING ANALGETIC HYDRAZONE DERIVATIVES OF 14-HYDROXYCODEINONE AND 14-HYDROXYMORPHINONEJ. Acta Pharmaceutica Sinica, 1983, 18(6): 475-477.
shu

长效镇痛药14-羟基可待因酮和14-羟基吗啡酮腙类衍生物的合成

SYNTHESIS OF LONG-ACTING ANALGETIC HYDRAZONE DERIVATIVES OF 14-HYDROXYCODEINONE AND 14-HYDROXYMORPHINONE

    摘要
  • Abstract: Five hydrazone derivatives of 14-hydroxycodeinone and 14-hydroxymorphinone were synthesized and evaluated in vivo as potential analgetic agents. Among them, 14-hydroxymorphinone hydrazone (Ⅲ-d) was selected for further study. It was nearly as potent as morphine with 4 fold duration of action.

     

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