Abstract: Five quinolone alkaloids (IVa, Va,c,d,g) including two new compounds (IVa, Vc) from Evodia rutaecarpa and nine analogs are synthesized in good yield by using acidcatalyzed condensation of a series of 3oxoalkkanoic acid esters with aniline and further methylized with methyl iodide. The other analogue Vh is prepared through the reaction of lithium enolate methyl ketone with nmethylisatoic anhydride. Eight compounds (IVa,d,f; Vb,c,d,f,h) were synthesized for the first time. Pharmacological studies showed that these compounds have vasoconstriction inhibiting and antiulcer effects. Compound IVb also has cytotoxic effect.