酸枣仁皂苷D的分离及结构鉴定

Structure identification of jujuboside D

摘要: 目的研究酸枣仁Ziziphus jujuba Mill var. Spinosa (Bunge) Hu ex. H.F.的化学成分。方法用多种色谱方法分离化学成分、鉴定结构。结果从正丁醇部分分离得到5个化合物，其结构分别为：酸枣仁皂苷D(1, jujuboside D)，酸枣仁皂苷A(2, jujuboside A)，5,7,4′-三羟基黄酮醇-3-O-β-D-鼠李糖(1→6)-β-D-葡糖苷(3), 5,4′-二羟基-7-甲氧基黄酮-6-C-6-对香豆酰基-β-D-葡萄糖(1→2)-β-D-葡糖苷(4, 6-coumaroylspinosin)及苯丙氨酸(5)。结论化合物1为新化合物，化合物4作为阻转异构体存在为首次报道，化合物3和5为首次从酸枣仁获得。

Abstract: AimTo study the chemical constituents of Ziziphus jujuba Mill var. Spinosa (Bunge) Hu ex. H.F.Chou. MethodsTo separate the constituents by using various kinds of chromatography and identify their structures on the basis of spectral analysis. ResultsFive compounds were isolated and their structures were established as jujuboside D (1), jujuboside A (2)，5,7,4′-trihydroxyflavonol-3-O-β-D-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (3), 6-coumaroylspinosin (4) and phenylalanine (5). ConclusionCompound 1 is a new compound named jujuboside D, 4 is reported as rotamer for the first time, 3 and 5 isolated from this plant for the first time.