Abstract: The effects of bepridil(Bep)in combination with anisodamine(Ani)on myocardial ischemia and reperfusion injury induced by ligating the left coronary artery were studied in rats Administration of a combination of Bep and Ani was found to decrease the incidence of arrhythmia induced by myocardial ischemia and reperfusion,increase the myocardial superoxide dismutase(SOD)activities and reduce the myocardial ultrastructural injury in rats.The effect of combination of Bep and Ani was shown to be better than either Bep or Ani alone.