高建华, 文广伶, 张其楷. 光学纯羟基醚类化合物的合成和分离J. 药学学报, 1987, 22(9): 708-710.
引用本文: 高建华, 文广伶, 张其楷. 光学纯羟基醚类化合物的合成和分离J. 药学学报, 1987, 22(9): 708-710.
GAO Jian-Hua. WEN Guang-Ling, ZHANG Qi-Kai, . THE SYNTHESIS AND SEPARATION OF OPTICALLY PURE HYDROXY ETHERSJ. Acta Pharmaceutica Sinica, 1987, 22(9): 708-710.
Citation: GAO Jian-Hua. WEN Guang-Ling, ZHANG Qi-Kai, . THE SYNTHESIS AND SEPARATION OF OPTICALLY PURE HYDROXY ETHERSJ. Acta Pharmaceutica Sinica, 1987, 22(9): 708-710.

光学纯羟基醚类化合物的合成和分离

THE SYNTHESIS AND SEPARATION OF OPTICALLY PURE HYDROXY ETHERS

  • Abstract: By using optically pure R and S 3-quinuclidinols. two pairs of diastereoisomers (R-1) and (R-2), (S-1) and (S-2) were synthesized. Each pair was further separated by preparative TLC. The mobile phase was chloroform-methanol-ammonia water (8:2:0.07). There is a marked distinction among their affinities for M-cholinergic receptor in rat hrain The work is still in progress.

     

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