中国红参化学成分的研究(Ⅱ)

STUDIES ON THE CHEMICAL CONSTITUENTS OF CHINESE RED GINSENG (Ⅱ)

摘要: 从中国红参(Panax ginseng C.A.Meyer)中分离出十种单体(RG 1～10),用IR.MS(FD-MS.FAB-MS)、¹³C-NMR以及化学方法等鉴定了化学结构,分别为20(R)-ginsenoside Rh,(RG-1),ginsenoside-Rg,(RG-2),20(R)-ginsenoside-Rg₂(RG-3),20(R)proto-panaxatriol(RG-4)以及人参皂甙Rg.(RG-5),—Re(RG-6)—Rd(RG-7),—RC(RG-8),—Rd₂(RG-9),—Rb,(RG-10);其中RG-1、RG-3、RG-4系首次从中国红参分离得到的人参皂甙成分。用薄层对照未炮制前的白参不含以上三种成分,这可能是红参与白参药理作用上差异的原因之一。

Abstract: From Chinese red ginseng (Panax ginseng. C. A. Meyer) ten saponins (RG1-10) were isolated. The structures of these saponins were identified on the basis of IR, Mass (FD-MS), ¹³C-NMR and chemical evidences, respectively with 20(R)-ginsenoside Rh₁ (RG-1), ginsenogside Rg₃ (RG-2), 20(R) ginsenoside Rg₂(RG-3), 20(R)protopanaxatriol (RG-4) and ginsenosides-Rg₁ (RG-5),-Re(RG-6), Rd(RG-7), -Rc(RG-8), -Rb₂(RG-9), -Rb₁(RG-10). three saponins RG-1, RG-2 and RG-4 were for the first time obtained from the Chinese red ginseng. These constituents may be one of the causes of difference of pharmacological activity between red ginseng and white ginseng.