尼莫地平多晶型的研究

王晋, 张汝华, 孙淑英. 尼莫地平多晶型的研究J. 药学学报, 1995, 30(6): 443-448.

引用本文:

王晋, 张汝华, 孙淑英. 尼莫地平多晶型的研究J. 药学学报, 1995, 30(6): 443-448.

J Wang, RH Zhang , SY Sun, . STUDIES ON THE POLYMORPHISM OF NIMODIPINEJ. Acta Pharmaceutica Sinica, 1995, 30(6): 443-448.

Citation:

J Wang, RH Zhang , SY Sun, . STUDIES ON THE POLYMORPHISM OF NIMODIPINEJ. Acta Pharmaceutica Sinica, 1995, 30(6): 443-448.

STUDIES ON THE POLYMORPHISM OF NIMODIPINE

摘要: 用不同有机溶剂重结晶制备了尼莫地平的两种晶型H和L,并通过红外光谱、X-射线粉末衍射、差热分析等方法得到证实。实验测定了尼莫地平两种晶型的溶解度曲线,并计算热力学数据。

Abstract: Two different polymorphic forms of nimodipine were found and prepared,and characterized by means of X-ray powder diffraction,DTA and IR.Equilibrium solubilities at 5 temperatures in water were determined and thermodynamic parameters were calculated.

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