头序楤木叶中三萜化学成分的研究

STUDIES ON TRITERPENOIDS AND THEIR GLYCOSIDES FROM ARALIA DASYPHYLLA MIQ

摘要: 从头序楤木(Aralia dasyphyla Miq)叶中分离到6个三萜化合物,用化学方法和波谱(UV,IR,MS,¹HNMR,¹³CNMR,¹³CDEPT,HMQC,HMBC)分析,确定其中4种化合物的结构,分别为齐墩果酸(I),16β-羟基-18β-H-齐墩果酸(I),齐墩果酸-28-O-β-D-吡喃葡萄糖甙(II)和16β-羟基-18β-H-齐墩果酸-28-O-β-D-吡喃葡萄糖甙(IV)。用NOESY谱确定化合物I的立体构型。以上4个化合物均为首次从该植物中分离到,化合物IV为新化合物。

Abstract: The structures of two triterpenoids and their glycosides were isolated from Aralia dasyphylla Miq. Their structures have been identified to be oleanoic acid(I), 16β-hydroxy-18β-H-oleanoic acid(II), oleanoic acid-28-O-β-D-glucopyranoside(III) and 16β-hydroxy-18β-H-oleanoic acid-28-O-β-D-glucopyranoside(IV), respectively, mainly through interpretation of UV, IR, MS, ¹H and ¹³CNMR, DEPT, HMQC and HMBC spectra data The stereochemistry of II has been confirmed by NOESY. Pharmacological experiments showed that the total saponins exerted preventative effect on CCl₄-induced liver injury of male mice and hypoglycemic effect on a model of alloxaninduced diabetes in rats.