陆彬, 卢丹. 吲哚美辛-PEG 6000滴丸的研究J. 药学学报, 1992, 27(3): 227-230.
引用本文: 陆彬, 卢丹. 吲哚美辛-PEG 6000滴丸的研究J. 药学学报, 1992, 27(3): 227-230.
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B Lu, D Lu. STUDY ON PILULES OF INDOMETHACIN-PEG 6000J. Acta Pharmaceutica Sinica, 1992, 27(3): 227-230.
Citation: B Lu, D Lu. STUDY ON PILULES OF INDOMETHACIN-PEG 6000J. Acta Pharmaceutica Sinica, 1992, 27(3): 227-230.
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吲哚美辛-PEG 6000滴丸的研究

STUDY ON PILULES OF INDOMETHACIN-PEG 6000

    摘要
  • 摘要: 以聚乙二醇6000(简称PEG 6000)为载体制成吲哚美辛滴丸。测得滴丸的溶解度比原药吲哚美辛增大一倍多,剂量减半时,滴丸对大鼠胃的刺激性显著降低,且仍有抑制基础胃酸分泌的作用。

     

    Abstract: Indomethacin (IDM)-PEG 6000 pilules were prepared using PEG6000as the carrier. The solubility of IDM in IDM-PEG 6000 pilules was about twiceas much as pure IDM. When the effective dose of IDM -PEG 6000 was only half that ofIDM tablet, the irritation of IDM-PEG 6000 pilule on rat stomach was reducedsignificantly but it still manifested the action of inhibiting the secretion of basal gastricacid

     

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