中国乌头之研究  ⅩⅨ  四川雪上一枝蒿中生物碱及其结构

STUDIES ON CHINESE DRUG ACONITUM SPP. XIX THE ALKALOIDS OF ACONITUM PENDULUM AND THEIR CHEMICAL STRUCTURE

摘要: 从四川金沙江畔雪上一枝蒿(Aconitum pendulum)中分出四个结晶性的生物碱,证明其中三个为已知生物碱,即次乌头碱(hypaconitine),乌头碱(aconitine)和3-乙酰乌头碱(3-acetylaconitine);另一种为新生物碱,暂称为雪乌碱(penduline)熔点166～167℃,分子式C₃₄H₄₇NO₉,结构式初步推定如下式所示。雪上一枝蒿中主要生物碱为乌头碱,得率约为0.14%;雪乌碱对动物具有镇痛局麻等作用。

Abstract: Three known alkaloids, hypaconitine, 3-acetylaconitine, and aconitine, and a new alkaloid named penduline, mp 166～177℃ C₃₄H₄₇NO₉, have been isolated from theroots of Aconitum pendulum collected on the side of the Jin-Sha River in Szechwan. Province.Acoording to spectral study, the structure of penduline was shown to be 3,13-deoxyaconitine.