Abstract: A new electrochemical stripping method for measuring the antipsychotic drug chlorprothixene was reported. The drug, Which was adsorbed on the surface of glassy carbon electrode, showed a sharp oxidative stripping peak at about+0.7V (vs. AgAgCl) in voltammetry. The response was linear over the 0.01～1μg/ml concentration range. The detection limit was 2ng/ml, about 400 times higher than UV method. The electrode surface was polished with alumina between the measurements to activate the electrode and provide good reproducibility. The open circuit accumulation / medium exchange/stripping voltammetry scheme has been proposed to avoid interference. The method has been used for direct determination of chlorprothixene in tablets and urine samples.