乙吗噻嗪胃内滞留漂浮型缓释片的研究

STUDIES ON ETHMOZINE SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACH

摘要: 研制了乙吗噻嗪胃内滞留漂浮型缓释片剂(E-HBS)。实验结果表明:本品的体外溶出符合一级动力学过程(Kr=0.2436h^-1);人体胃内γ-闪烁照像显示E-HBS在胃内滞留时间长达6h以上,明显长于市售普通片(ECT1～1.5h);血药浓度经时曲线平缓持久,达到良好的缓释效果;体内外实验数据有显著的相关性(P<0.01)。

Abstract: An oral sustained-release system of cthmozm0(E-HBS)was developed.The in vitro release characteristics of E-HBS were shown primarily to be of the first order of kinetics(Kr=0.2436h^-1).The γ-scintiphotographic study showed that E-HBS remained in the human stomach formore than 6 hours after ingestion,much longer than the conventional tablet(1～1.5h).The plasmaconcentration-time curve of E-HBS exhibited typical sustained-release characteristics.The percentageof drug released in vitro vs the percentage of drug release in vivo of E-HBS indicated excellent linearity.