Abstract: This work was undertaken to invgate the application of nonaqueous titration to the determination of tablets of anti-malarial drugs, with the view of finding out a simple, rapid and accurate method of analysis. Eleven kinds of tablets have been determined and the results as compared with those by the official methods are satisfactory. With the elimination of tedious extractions and evaporation of the solvent, a method is proposed as follows: Dissolve the finely pulverized and accurately weighed sample of about 0.5 milliequivalent weight of 1N HCl, in a 100ml Erlenmeyer flask and digest on a water bath for 10 min. After cooling, the solution, made alkaline with 3ml of 6N NaOH, is cooled under tap water and extracted with 30ml of chloroform with vigorous shaking for 10 min. Add 1 gm of tragacanth powder, shake for 2 min. till the solution becomes clear (if it remains turbid, add one more gm of tragacanth powder and shake) and filter through absorbent cotton. Titrate 20 ml of the clear filtrate with acetous perchloric acid, using 1 drop of crystal violet solution as indicator, to the end point which is blue for colorless sample or green without red tint for yellow-colored sample. A blank is run.