Abstract: General saponin is the major effective substance in the fibrous root of Panax notoginseng (Burk) F. H. Chen, and sanchinoside C₁ is the main constitueet of this general saponin. Their effects on blood sugar were Studied on experimental animals. It was found that oral administration of sanehinoside C₁ in mice, was followed, by a slight rise in fasting blood sugar and a fall to normal level in hyperglycemia. But sanchinoside C₁ showed no influence on hyperglycemia induced by adrenalin.General saponin of Panax notoginseng can also raise the fasting blood sugar level in mice and decreases the hyperglycemia in mice and rabbits, but it did not influence on the ability of insulin in reducing blood sugarln rabbits. The effect of this general saporiin differs from sanchinoside C₁ in that the latter increases hyperglycemia induced by adrenalin in mice and rabbits.