Abstract: AimTo establish a method for the determination of the five components (reserpine, chlordiazepoxide, hydrochlorothiazide, dihydralazine sulfate, triamterene) in compound hypotensive tablet. MethodsThe chromatography was performed using a CN column with acetontrile-0.1 mol L^-1 sodium heptasulfonate solution (7∶3) and (5∶5) as the mobile phases. The detection wavelength was 267 nm for reserpine, chlordiazepoxide and hydrochlorothiazide, 310 nm for dihydralazine sulfate, 360 nm for triamterene. ResultsThe linear range of each component was tested, and the recovery and stability of each component was satisfactory, three lots of samples were determined using the method. Conclusion This is an accurate and credible quality control method for compound hypotensive tablet.