人尿中沙丁胺醇的测定

DETERMINATION OF SALBUTAMOL IN HUMAN URINE

摘要: 采用GC—Ms联用技术，对尿中的沙丁胺醇(salbutamol)进行分析。实验表明，口服一片沙丁胺醇(2．4 mg)，可于24 h从尿中排泄，且以游离形式为主。样品提取时，控制溶液pH为8.8时，提取率较高。本方法对沙丁胺醇定性简单、快速、准确。

Abstract: Salbutamol(2.4 mg)was administrated to a healthy male．The urine was analysed by GC—MS．95% of the drug was excreted in 24 h in unconjugated form．The pH of urine was shown to strongly affect the extraction rate，good recovery was obtained at pH 8.8．With this method，salbutamol can be determined simply，quickly and accurately．