Abstract: AimTo prepare a novel creatinine adsorbent with anti-renal failure activity. MethodsA novel starch ester was prepared under heterogeneous condition by the reaction of starch (ST) and 3,5-dinitrobenzoyl chloride (DNBZ-Cl). The products were characterized by means of elemental analysis, FTIR, ¹³CNMR and UV-Vis spectra. The adsorption properties of DNBZ-ST were examined. ResultsThe adsorption equilibrium is reached after 4 h, the adsorption capacity increases with the degree of substitution (DS) of adsorbent and creatinine concentration. When creatinine concentration is higher than 300 mg·L^-1, concentration showed no apparent effect on adsorption capacity. As the adsorption temperature varied from 19 ℃ to 49 ℃, adsorption capacity first decreases and then increases, and is lowest at 37 ℃. The adsorption capacity first increases and then decreases as the pH value increase from 4 to 11 and is highest at pH 8. The highest adsorption capacity reached 25 mg·g^-1 at 37 ℃ pH 7 and the creatinine concentration is 100 mg·L^-1. ConclusionStarch 3,5-dinitrobenzoate showed a better adsorption property for creatinine, and it is worthy to be studied more deeply.