广西特产植物罗汉果根的化学成分研究

STUDIES ON THE CHEMICAL CONSTITUENTS FROM THE ROOT OF SIRAITIA GROSVENORII

摘要: 目的:对罗汉果(Siraitia grosvenorii(Swingle) C.Jeffrey)根中抗癌活性成分进行研究。方法:用正反相硅胶柱及Sephadex LH20 柱进行分离,根据光谱(UV,IR,MS,ID-及,2D-NMR) 分析,鉴定化合物结构。结果:分得4个葫芦烷型四环三萜酸: 罗汉果酸甲(I),罗汉果酸乙(II) ,罗汉果酸丙(III)和罗汉果酸戊(IV) 。结论:罗汉果酸戊为新化合物,罗汉果酸乙在体外有明显的抗癌活性。

Abstract: AIM: To look for new compounds with anti tumor activity from the root of Siraitia grosvenorii. METHODS: The compounds were separated by chromatography on silica gel and Sephadex LH20. Their structures were determined by spectral analysis. RESULTS: Four compounds have been isolated from the root of Siraitia grosvenorii, they have been identified as siraitic acid A(I), B(II), C(III) and E(IV). CONCLUSION: Siraitic acid E is a new compound; preliminary antitumor test showed that siraitic acid B exhibited significant activity in vitro.