酞丁安制剂对豚鼠皮肤疱疹病毒感染的作用

THE EFFICACY OF TAI-DING-AN ON THE INHIBITION OF HSV-I SKIN INFECTIONS IN GUINEA PIGS

摘要: 本文报道酞丁安不同制剂对豚鼠皮肤单纯疱疹Ⅰ型病毒感染局部治疗的效果.0.75～1%酞丁安—60%二甲基亚砜溶液在疱疹病毒感染后24 h开始治疗,一天四次涂擦感染部位4～5天,可显著抑制皮肤病损的发展,有治疗效果,2%酞丁安—60%二甲基亚砜溶液在室温放置析出结晶,沉着于皮损表面,影响疗效。0.25%酞丁安—25%二甲基亚砜无效。2%酞丁安冷霜有效,2%软膏有刺激作用,无效。

Abstract: Tai-DingyAn (TDA) is a derivative of thiosemicarbazone with anti-Chlamydozoa trachomatis activity and was used in clinic for treatment of trachoma in China. Tai-Ding-An was found to have anti-herpetic activities both in cell cultures and in guinea pig skin infections. Tai-Ding-An is insoluble in water but soluble in DMSO. 1～2% TDA in 60% DMSO applied topically on HSV-Ⅰ infected guinea pig skin, QID for 5 days. started 24 hrs after infection significantly inhibited the development of skin lesions. Since 2% TDA in 60% DMSO is a saturated solution, TDA precipitated on the skin and interfered with the healing of the lesions, so that it was less active than that of 1% TDA. 0.25% TDA in 25% DMSO and 2% TDA paste gave no significant therapeutic effect.