Abstract: In addition to the known cycleanine (Ⅰ) and d-isochondodendrine (Ⅱ), two novel bisbenzylisoquinoline alkaloids named isocycleanine (Ⅲ) and sutchuenensine (Ⅳ) have been isolated from the roots of Cyckea sutchuenensis Gagnep grown wild in Sichuan province, China. Ⅲ was established as the epimer of Ⅰ and Ⅳ, as a new type of head-to-tail bisbenzylisoquinoline alkaloid with two diarylether bridges in between C-8 to C-12′ and C-12 to C-7′ on the basis of physical constants and spectral data (UV, IR, ELMS, ¹HNMR and NOEDS).