吴继洲, 阮汉利, 姚念环, 孙汉董, 森实千香子, 饭田彰, 藤多哲朗. 鄂贝缩醛A的结构解析与合成J. 药学学报, 1999, 34(8): 600-604.
引用本文: 吴继洲, 阮汉利, 姚念环, 孙汉董, 森实千香子, 饭田彰, 藤多哲朗. 鄂贝缩醛A的结构解析与合成J. 药学学报, 1999, 34(8): 600-604.
shu
Wu Jizhou, Ruan Hanli, Yao Nianhuan Sun H,ong, Morizane C, Iida A　,　Fujitd T, . STRUCTURAL ELUCIDATION AND SYNTHESIS OF FRITILLEBINIDE A FROM BULBS OF FRITILLARIA EBEIENSISJ. Acta Pharmaceutica Sinica, 1999, 34(8): 600-604.
Citation: Wu Jizhou, Ruan Hanli, Yao Nianhuan Sun H,ong, Morizane C, Iida A　,　Fujitd T, . STRUCTURAL ELUCIDATION AND SYNTHESIS OF FRITILLEBINIDE A FROM BULBS OF FRITILLARIA EBEIENSISJ. Acta Pharmaceutica Sinica, 1999, 34(8): 600-604.
shu

鄂贝缩醛A的结构解析与合成

STRUCTURAL ELUCIDATION AND SYNTHESIS OF FRITILLEBINIDE A FROM BULBS OF FRITILLARIA EBEIENSIS

    摘要
  • 摘要: 目的：研究民间药鄂北贝母Fritillaria ebeiensis G.D.Yu et G.Q.Ji鳞茎的非生物碱成分。方法：用MeOH提取，反复硅胶柱色谱分离与纯化，经理化常数测定、波谱解析、化学合成及降解反应，确定其结构。结果：从乙酸乙酯萃取物中分离鉴定了1个二萜，其结构为ent-kauran-16β,17-acetal ent-16β-kauran-17(S)-aldehyde (1)。结论：化合物1为新的对映-贝壳杉烷型缩醛聚合二萜,命名为鄂贝缩醛A(fritillebinide A)。

     

    Abstract: AIM: To sutdy the non-basic constituents of the Chinese herbal drug “Ebeibeimu”, the bulus of Fritillaria ebeiensis G.D.Yu et G.Q.Ji, in order to appraise its quality systematically. METHODS: MeOH extraction and silica gel column chromatography were to isolate pure compound, its structure was determined with various spectral analysis including 2D-NMR techniques and chemical methods. RESULTS: A diterpenoid has been isolated from the EtOAc fraction of the bulus of Fritillaria ebeiensis, growing in the Suizhou disrtict of Hubei province, China. It was established as ent-kauran-16β,17-acetal ent-16β-kauran-17(S)-aldehyde (1) on the basis of physicochemical and spectral data and chemical synthesis. CONCLUSION: Compound 1 is a novel acetal diterpenoid dimer with ent-kaurane skeleton, named fritillebinide A.

     

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