Abstract: Eleven 5-nitrofurfurylidene mono-and di-substituted acetophenones with possible schistosomicidal activity have been prepared by condensation of furfural with the requisite substituted acetophenones in alcoholic sodium hydroxide, followed by nitration. Attempts to prepare 5-nitrofurfurylidene-p-hydroxyacetophenone and 5-nitrofurfurylidene p-dimethylaminoacetophenone by nitration failed; the crude products could not be recrystallized. None of these compounds was found effective against experimental schistosomiasis On mice.