Abstract: A series of 5-(1,2-substituted benzimidazolyl)-N, N-dimethyl carbamates had been synthesized. The N-alkyl-4-methoxy-2-nitroanilides were converted into the 1,2-dialkyl-5-methoxy benzimidazoles by reductive cyclization. The technique of phase transfer cataiysis was successfully used in the N-alkylation of anilides and the N,N-dimethyl carbamylation of 5-hydroxybenzimidazoles.The bioactivity on cholinesterases of all these compounds have been tested. The methoiodides were found to be more active than the hudrochlorides.