朱传江, 张均田. (-),(+)-7-羟基-黄皮酰胺对大鼠海马齿状回突触传递功能的影响(-),(+)-7-羟基-黄皮酰胺对大鼠海马齿状回突触传递功能的影响J. 药学学报, 2004, 39(1): 34-36.
引用本文: 朱传江, 张均田. (-),(+)-7-羟基-黄皮酰胺对大鼠海马齿状回突触传递功能的影响(-),(+)-7-羟基-黄皮酰胺对大鼠海马齿状回突触传递功能的影响J. 药学学报, 2004, 39(1): 34-36.
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ZHU Chuan-jiang, ZHANG Jun-tian. Effects of (-), (+)-7-hydroxy-clausenamide on synaptic transmission in rat dentate gyrus in vivoJ. Acta Pharmaceutica Sinica, 2004, 39(1): 34-36.
Citation: ZHU Chuan-jiang, ZHANG Jun-tian. Effects of (-), (+)-7-hydroxy-clausenamide on synaptic transmission in rat dentate gyrus in vivoJ. Acta Pharmaceutica Sinica, 2004, 39(1): 34-36.
shu

(-),(+)-7-羟基-黄皮酰胺对大鼠海马齿状回突触传递功能的影响(-),(+)-7-羟基-黄皮酰胺对大鼠海马齿状回突触传递功能的影响

Effects of (-), (+)-7-hydroxy-clausenamide on synaptic transmission in rat dentate gyrus in vivo

    摘要
  • 摘要: 目的观察(-),(+)-7-羟基-黄皮酰胺(7-hydoxy-clausenamide,7-OH-Clau)对大鼠海马齿状回基础突触传递功能的影响。方法细胞外记录低频刺激(1/30 Hz,1.0 mA)引起的海马齿状回群峰电位(population spike, PS)。结果侧脑室注入脑终浓度为2×10-6 mol·L-1 (-)-7-OH-Clau后15,30,60 min,PS幅值比给药前均增加了30%以上,比空白对照组增加了27%～41%;而同剂量的(+)-7-OH-Clau在注射后的3个时间点上,PS幅值比给药前下降了18%～25%,比空白对照组下降了11%～20%。结论(-)-7-OH-Clau能增强大鼠海马齿状回的基础突触传递活动,而(+)-7-OH-Clau对这种活动显示出抑制作用。

     

    Abstract: AimTo investigate effects of (-), (+)-7-hydroxy-clausenamide (7-OH-Clau) on basal synaptic transmission in the dentate gyrus of anesthetized rats. MethodsExtracellular recording of the population spike (PS) of hippocampal dentate gyrus following application of low-frequency stimulation (1/30 Hz, 1.0 mA). ResultsFifteen, thirty and sixty minutes after intracerebroventricular (icv) administration of an estimated final brain concentration of 2×10-6 mol·L-1, (-)-7-OH-Clau caused over 30% increase relative to basal PS amplitude before administration, and 27%-41% increase relative to vehicle control (P<0.05), while (+)-7-OH-Clau exhibited 18%-25% and 11%-20% decrease in the PS amplitude when compared with basal PS amplitude and vehicle control (P<0.05), respectively. ConclusionThe basal synaptic transmission in the dentate gyrus of the rat hippocampus can be potentiated by (-)-7-OH-Clau and attenuated by (+)-7-OH-Clau, indicating that there was a stereoselective difference between the two enantiomers in the modulation of synaptic responses and plasticity.

     

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