张淑瑜, 汤海峰, 易杨华, 李玲, 周大铮, 邹峥嵘. 太平洋侧花海葵中四个新神经酰胺的鉴定太平洋侧花海葵中四个新神经酰胺的鉴定J. 药学学报, 2003, 38(5): 350-353.
引用本文: 张淑瑜, 汤海峰, 易杨华, 李玲, 周大铮, 邹峥嵘. 太平洋侧花海葵中四个新神经酰胺的鉴定太平洋侧花海葵中四个新神经酰胺的鉴定J. 药学学报, 2003, 38(5): 350-353.
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ZHANG Shu-yu, TANG Hai-feng, YI Yang-hua, LI Ling, ZHOU Da-zheng, ZOU Zheng-rong. Identification of four new ceramides from Anthopleura pacificaJ. Acta Pharmaceutica Sinica, 2003, 38(5): 350-353.
Citation: ZHANG Shu-yu, TANG Hai-feng, YI Yang-hua, LI Ling, ZHOU Da-zheng, ZOU Zheng-rong. Identification of four new ceramides from Anthopleura pacificaJ. Acta Pharmaceutica Sinica, 2003, 38(5): 350-353.
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太平洋侧花海葵中四个新神经酰胺的鉴定太平洋侧花海葵中四个新神经酰胺的鉴定

Identification of four new ceramides from Anthopleura pacifica

    摘要
  • 摘要: 目的研究太平洋侧花海葵(Anthopleura pacifica)中的生物活性成分。方法采用稻瘟霉模型生物活性追踪方法,应用色谱技术进行分离,根据理化性质和波谱分析鉴定结构。结果得到了1个对稻瘟霉显示活性的组分,并鉴定为4个神经酰胺的混合物:N-羟乙基-N-十四酰-(2S,3R)-十八碳鞘氨醇-4(E),8(E)-二烯(a),N-羟乙基-N-(9Z-十六烯酰)-(2S,3R)-十八碳鞘氨醇-4(E),8(E)-二烯(b),N-羟乙基-N-十六酰-(2S,3R)-十八碳鞘氨醇-4(E),8(E)-二烯(c)和N-羟乙基-N-(13Z-二十二烯酰)-(2S,3R)-十八碳鞘氨醇-4(E),8(E)-二烯(d)。结论化合物a～d均为新的神经鞘氨醇化合物。

     

    Abstract: AimTo study the bioactive constituents from Anthopleura pacifica. MethodsCompounds were separated by Pyricularia oryzae bioassay-guided fractionation method with a combination of multi-chromatography. Their chemical structures were determined on the basis of spectral analysis and chemical evidence. ResultsA portion showing activity against P. oryzae was obtained and from the portion four compounds were identified as N-hydroxyethyl-N-tetradecanoyl-(2S,3R)-octadecasphinga-4(E), 8(E)-dienine(a), N-hydroxyethyl-N-(9Z-hexadecenoyl)-(2S,3R)-octadecasphinga-4(E), 8(E)-dienine(b), N-hydroxyethyl-N-hexadecanoyl-(2S,3R)-octadecasphinga-4(E), 8(E)-dienine (c) and N-hydroxyethyl-N-(13Z-docosenoyl-(2S,3R)-octadecasphinga-4(E), 8(E)-dienine(d). ConclusionAll the four compounds are new ceramides.

     

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