自旋标记的鬼臼葡萄糖苷衍生物的合成

鲁宽科, 陈耀祖. 自旋标记的鬼臼葡萄糖苷衍生物的合成J. 药学学报, 1998, 33(12): 948-950.

引用本文:

鲁宽科, 陈耀祖. 自旋标记的鬼臼葡萄糖苷衍生物的合成J. 药学学报, 1998, 33(12): 948-950.

Lu Kuank, Chen Yaozu. SYNTHESIS OF SPIN LABELED ANALOGUE OF PODOPHYLLOTOXIN GLYCOSIDEJ. Acta Pharmaceutica Sinica, 1998, 33(12): 948-950.

Citation:

Lu Kuank, Chen Yaozu. SYNTHESIS OF SPIN LABELED ANALOGUE OF PODOPHYLLOTOXIN GLYCOSIDEJ. Acta Pharmaceutica Sinica, 1998, 33(12): 948-950.

SYNTHESIS OF SPIN LABELED ANALOGUE OF PODOPHYLLOTOXIN GLYCOSIDE

Abstract: A novel spin labeled analogue of podophyllotoxin glycoside 9 was synthesized by condensing 4′-demthyl-epipodophyllotoxin-β-D-glucopyranose and 4-formyl-2,2,6,6-tetrahydropuridine in presence of p-TsOH and triethyl orthoformate. It was shown to exhibit activity compatable to VP-16-213 in inhibiting L₁₂₁₀ cells.

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