郭宗儒. 三嗪类化合物对小鼠成淋巴细胞瘤离体二氢叶酸还原酶活性和对瘤细胞生长抑制作用的定量相关关系J. 药学学报, 1983, 18(2): 125-129.
引用本文: 郭宗儒. 三嗪类化合物对小鼠成淋巴细胞瘤离体二氢叶酸还原酶活性和对瘤细胞生长抑制作用的定量相关关系J. 药学学报, 1983, 18(2): 125-129.
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GUO Zongru. COMPARISON OF INHIBITORY EFFECTS OF TRIAZINES ON DIHYDROFOLATE REDUCTASE ISOLATED. FROM MURINE LEEKEMIA CELLS WITH. THE INHIBITION OF GROWTH OF CELLS IN CULTUREJ. Acta Pharmaceutica Sinica, 1983, 18(2): 125-129.
Citation: GUO Zongru. COMPARISON OF INHIBITORY EFFECTS OF TRIAZINES ON DIHYDROFOLATE REDUCTASE ISOLATED. FROM MURINE LEEKEMIA CELLS WITH. THE INHIBITION OF GROWTH OF CELLS IN CULTUREJ. Acta Pharmaceutica Sinica, 1983, 18(2): 125-129.
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三嗪类化合物对小鼠成淋巴细胞瘤离体二氢叶酸还原酶活性和对瘤细胞生长抑制作用的定量相关关系

COMPARISON OF INHIBITORY EFFECTS OF TRIAZINES ON DIHYDROFOLATE REDUCTASE ISOLATED. FROM MURINE LEEKEMIA CELLS WITH. THE INHIBITION OF GROWTH OF CELLS IN CULTURE

    摘要
  • 摘要: 三嗪类化合物对瘤细胞生长的抑制作用,和对自瘤细胞分离的二氢叶酸还原酶活性的抑制作用的差异,经多重回归分析建立的模型表明,与化合物的克分子折射呈负性相关。瘤组织酶与正常酶活性的抑制作用呈平行关系。

     

    Abstract: Correlations between the inhibitory activity on dihydrofolate reductase isolated from murine leukemia ceils and the inhibition of the growth of the cells in culture by 4 , 6-diamino-1,2-dihydro-2, 2-dimethyl-1-(3-substituted phenyl)-s-triazines were undertaken.

     

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