裂叶铁线莲茎中两个新的酚苷类化合物(英文)

闫利华 徐丽珍 王智民 张启伟 杨世林

裂叶铁线莲茎中两个新的酚苷类化合物(英文)

闫利华徐丽珍王智民张启伟杨世林

Two new phenolic glycosides from the stems of Clematis parviloba

YAN Li-Hua

摘要

摘要:
为了研究裂叶铁线莲茎的化学成分, 采用硅胶、ODS、Sephadex LH-20柱色谱及半制备高压液相色谱等技术, 从其95%乙醇提取物中分离得到6个化合物。根据理化性质和波谱数据鉴定化合物结构分别为: 2-((E)-3- carboxybut-2-en-yl)-4-hydroxy-3-methyl-phenyl-O-β-D-glucopyranoside (1)、4'-hydroxy-phenol-β-D-6-O-(4''-hydroxy- 3'', 5''-dimethoxy-benzoate)glucopyranoside (2)、4'-hydroxy-3'-methoxy-phenol-β-D-6-O-(4''-hydroxy-3'', 5''-dimethoxy- benzoate) glucopyranoside (3)、linarionoside A (4)、linarionoside C (5) 和staphylionoside K (6)。其中, 化合物1～3为酚苷类化合物, 化合物4～6为大柱烷苷类化合物; 化合物1和2为新化合物, 分别命名为clemaparvilosides A (1) 和B (2); 化合物3～6均为首次从该属植物中分离得到。

Abstract:
To study the chemical constituents of the stems of Clematis parviloba, six compounds were isolated from a 95% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel, ODS, Sephadex LH-20, and semi-preparative HPLC. Two new phenolic glycosides, 2-((E)-3-carboxybut-2-en-yl)-4-hydroxy-3-methyl-phenyl-O-β-D-glucopyranoside (1) and 4'-hydroxy- phenol-β-D-6-O-(4''-hydroxy-3'', 5''-dimethoxy-benzoate) glucopyranoside (2) were isolated, together with a known phenolic glycoside, 4'-hydroxy-3'-methoxy-phenol-β-D-6-O-(4''-hydroxy-3'', 5''-dimethoxy-benzoate) glucopyranoside (3) as well as three known megastigmane glycosides, linarionoside A (4), linarionoside C (5), and staphylionoside K (6). Their structures were determined on the basis of spectroscopic analysis and chemical evidence. Among them, compounds 1 and 2 were named as clemaparvilosides A (1) and B (2), respectively, and compounds 3 − 6 were obtained from Clematis genus for the first time.

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