Abstract: Sinenxan A is a new biosynthetic taxane. In order to search for new taxol analogues with cytotoxicity, sinenxan A was modified and studied.Ten new taxoids containing the tetrahydrofuran ring were esterified at C₁₄ or C₁₀ positions with taxol/taxotere side chain. Preliminary pharmacological tests showed that some of the compounds have certain cytotoxicity on KB, HCT-8 and A₂₇₈₀. Meanwhile, the relationship between their structures and activity was discussed.