赵晓宏, 陈迪华, 斯建勇, 潘瑞乐, 沈连钢. 中药升麻酚酸类化学成分研究J. 药学学报, 2002, 37(7): 535-538.
引用本文: 赵晓宏, 陈迪华, 斯建勇, 潘瑞乐, 沈连钢. 中药升麻酚酸类化学成分研究J. 药学学报, 2002, 37(7): 535-538.
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ZHAO Xiao-hong, CHEN Di-hua, SI Jian-yong, PAN Rui-le, SHEN Lian-gang. STUDIES ON THE PHENOLIC ACID CONSTITUENTS FROM CHINESE MEDICINE “SHENG-MA”,RHIZOME OF CIMICIFUGA FOETIDA L.J. Acta Pharmaceutica Sinica, 2002, 37(7): 535-538.
Citation: ZHAO Xiao-hong, CHEN Di-hua, SI Jian-yong, PAN Rui-le, SHEN Lian-gang. STUDIES ON THE PHENOLIC ACID CONSTITUENTS FROM CHINESE MEDICINE “SHENG-MA”,RHIZOME OF CIMICIFUGA FOETIDA L.J. Acta Pharmaceutica Sinica, 2002, 37(7): 535-538.
shu

中药升麻酚酸类化学成分研究

STUDIES ON THE PHENOLIC ACID CONSTITUENTS FROM CHINESE MEDICINE “SHENG-MA”,RHIZOME OF CIMICIFUGA FOETIDA L.

    摘要
  • 摘要: 目的寻找中药升麻(Cimicifuga foetida L.)的有效成分.方法利用硅胶柱及Sephadex LH-20柱进行分离纯化,根据理化性质和各种波谱数据(UV,IR,MS,1D及2D-NMR),辅以化学方法,进行结构鉴定.结果从升麻生药乙醇提取物分离的酚酸性部分获得了8种成分:升麻酸(cimicifugic acid,1),马栗树皮素(esculetin,2),咖啡酸甲酯(caffeic acid methyl ester,3),4-氧-乙酰基咖啡酸(4-O-acetyl-caffeic acid,4),芥子酸(sinapic acid,5),咖啡酸(caffeic acid,6),阿魏酸(ferulic acid,7),异阿魏酸(isoferulic acid,8).结论 1为新的化合物,命名为升麻酸;2～7为首次从该生药中分得.

     

    Abstract: AIM To look for new active constituents from Chinese medicine“Sheng-ma”, rhizome of Cimicifuga foetida L. METHODS The compounds were separated and purified by chromatography on silica gel and Sephadex LH-20. Their structures were determined by spectral analysis and chemical reaction. RESULTS Eight compounds were obtained and identified as cimicifugic acid (1), esculetin (2), caffeic acid methyl ester (3), 4-O-acetyl-caffeic acid (4), sinapic acid (5), caffeic acid (6), ferulic acid (7), isoferulic acid (8). CONCLUSION Compound 1 is a new compound, and compounds 2～7 were isolated from this plant for the first time.

     

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