陆阳, 姚天荣, 陈泽乃. 凹脉丁公藤化学成分的研究J. 药学学报, 1986, 21(11): 829-835.
引用本文: 陆阳, 姚天荣, 陈泽乃. 凹脉丁公藤化学成分的研究J. 药学学报, 1986, 21(11): 829-835.
LU Yang, YAO Tian-Rong , CHEN Ze-Nai, . STUDIES ON THE CONSTITUENTS OFERYCIBE ELLIPTLLIMBAJ. Acta Pharmaceutica Sinica, 1986, 21(11): 829-835.
Citation: LU Yang, YAO Tian-Rong , CHEN Ze-Nai, . STUDIES ON THE CONSTITUENTS OFERYCIBE ELLIPTLLIMBAJ. Acta Pharmaceutica Sinica, 1986, 21(11): 829-835.

凹脉丁公藤化学成分的研究

STUDIES ON THE CONSTITUENTS OFERYCIBE ELLIPTLLIMBA

  • 摘要: 自凹脉丁公藤(Erycibe elllptilimba Merr.et Chun)中分得两个香豆素和三个生物碱。经鉴定分别为东莨菪素(scopoletin Ⅰ),东莨菪甙(scopolin Ⅱ),包公藤甲素(Ⅲ),包公藤丙素(Ⅳ)和一新的水溶性生物碱,结构为2β,7β-二羟基去甲茛菪烷,命名为凹脉丁公藤碱(erycibelline,Ⅴ)。包公藤丙素(Ⅳ)是首次分离得到纯品,其O-二乙酰化物(Ⅳa)具有缩瞳活性。

     

    Abstract: Five compounds have been isolated from the stem of Erycibe elliptilimba Merr. et Chun. By spectral analyses and chemical reactions four of them have been identified as scopoletin(Ⅰ), scopolin(Ⅱ), Bao-Gong-Teng A(Ⅲ),and Bao-Gong-Teng C(Ⅳ). (Ⅰ) and (Ⅱ) can be used as antirheumatic and analgesic; while (Ⅲ) can be used as myotic. The fifth one, 2β, 7β-dihydroxynortropane, is a new alkaloid named erycibelline(Ⅴ). Forthe first time (Ⅳ)is obtained as a pure colorless oil. It has been found that although (Ⅳ) Showed no obvious biologic activity, its O-diacetyl derivative (Ⅳa) is a strong myotic.

     

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