Abstract: AimTo observe the effect of phenolic alkaloids of Menispermum dauricum （PAMD） on the hemodynamics, coronary circulation and oxygen metabolism of the myocardium in anesthetized dogs. Methods In this study, the changes of LVSP, LVEDP and ±dP/dt_max, the flow of coronary artery and myocardial energy metabolism were measured in anesthetized dog with PAMD or NS. ResultsIn the anesthetized dogs, compared with pre-treatment status, PAMD at 3.5 and 7.0 mg·kg^-1 caused decreases in the left ventricular systolic pressure(LVSP),±dP/dt_max, heart rate, the rate of oxygen utilization, the coronary and general peripheral resistance. It was found to increase myocardial oxygen and coronary flow. There were no significant change in the left ventricular end diastolic pressure (LVEDP). ConclusionPAMD can ameliorate hemodynamics, coronary circulation and myocardial metabolism.