国产沉香化学成分的研究——Ⅲ.异白木香醇的结构测定和低沸点成分的分离与鉴定

STUDIES ON THE CHEMICAL CONSTITUENTS OF AQUILARIA SlNENSIS (LOUR.) GILG. Ⅲ. ELUCIDATION OF THE STRUCTURE OF ISOBAIMUXINOL AND ISOLATION AND IDENTIFICATION OF THE CONSTITUENTS OF LOWER BOILING FRACTION oF THE VOLATILE OIL

摘要: 自国产沉香(Aquilaria sinensis)瑞香科(Thymeleaceae)植物的挥发油中,经硅胶柱层析和离心薄层层析分离得到一新的倍半萜,命名为异白木香醇(isobaimuxinol),根据光谱(IR,¹HNMR,¹³CNMR,2 D-NMR和MS)分析确定其结构式为(Ⅰ)所示,并用X-光衍射晶体解析进一步确定了其立体化学。同时,也从该植物挥发油的低沸点部分分离得到四个已知化合物:苄基丙酮,对甲氧基苄基丙酮,茴香酸和β-沉香呋喃。这些化合物均为首次从该植物中得到。

Abstract: A new sesquiterpenoid, named isobaimuxinol, C₁₅H₂₆O₂, mp 73～75℃, α_D¹²—68° (c0.10, CHC1₃), was isolated from the volatile oil of Aquilaria sinensis (Lout.) Gilg. (Thymeleaceae). Based on. spectral (IR,¹H-NMR, ¹³C-NMR and 2D-NMR as well as MS) analysis its structute was identified as isobaimuxinol The relative stereochemistry of isobaimuxinol was determined by X-ray crystallograhy.In addition, four known compounds, benzylacetone, p-methoxybenzylacetone, anisic acid and β-agarofuran were isolated and identified from the lower boiling fraction of the volatile oil of this plant. These compounds were obtained for the first time from this plant.